Facile synthetic route to cone-shaped phosphorylated [CH2P(O)Ph2] calix[4]arenes

Abstract
Selective incorporation of one, two or four CH2P(O)Ph2 substituents at specific sites in para-tert-butylcalix[4] arene was achieved using NaH and an appropriate alkylating agent; the tetrasubstituted compound (structure established by X-ray crystallography) was quantitatively reduced to the corresponding tetraphosphine L6 which, by reaction with [{Pd(C6H4CH2NMe2-o)Cl}2], gave access to the tetranuclear complex [{Pd(C6H4CH2NMe2-o)Cl}4L6].

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