Retinal Progenitor Cell Xenografts to the Pig Retina
Open Access
- 1 October 2005
- journal article
- laboratory sciences
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 123 (10) , 1385-1393
- https://doi.org/10.1001/archopht.123.10.1385
Abstract
The major diseases of the retina, including retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy, are quite heterogeneous with respect to etiology, pathology, and demographics, yet have in common the unifying feature of neuronal loss. As in the brain and spinal cord, loss of neurons in the retina is permanent, and there are at present no restorative treatments available for these conditions. One approach to neuronal repopulation that has been actively investigated is the transplantation of embryonic or fetal retinal tissue. Achieving widespread functional integration of transplanted retinal tissue in the diseased retina has proved to be elusive1; however, neural progenitor cells have recently demonstrated considerable potential as an alternative to fetal tissue in the setting of transplantation.Keywords
This publication has 23 references indexed in Scilit:
- Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitorsBiomaterials, 2005
- IMPORTANCE OF THE GAL α1–3 GAL ANTIGEN IN DISCORDANT ISLET XENOTRANSPLANTATION: IMMUNOSUPPRESSION, WHICH INHIBITS PORCINE ISLET XENOGRAFT REJECTION IN ORDINARY MICE, IS EQUALLY EFFECTIVE IN GAL-KNOCKOUT MICETransplantation, 2004
- CD86 Blockade in Genetically Modified Porcine Cells Delays Xenograft Rejection by Inhibiting T-Cell and NK-Cell ActivationCell Transplantation, 2004
- Survival and integration of neural retinal transplants in rd miceAlbrecht von Graefes Archiv für Ophthalmologie, 2003
- Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent dataVision Research, 2003
- Incorporation of Murine Brain Progenitor Cells into the Developing Mammalian RetinaInvestigative Opthalmology & Visual Science, 2003
- Retinal Integration of Grafts of Brain-Derived Precursor Cell Lines Implanted Subretinally into Adult, Normal RatsExperimental Neurology, 2001
- Transplantation of Human Neural Progenitor Cells to the Vitreous Cavity of the Royal College of Surgeons RatCell Transplantation, 2001
- Multipotent Stem Cells from the Brain and Retina of Green MiceE-Biomed: The Journal of Regenerative Medicine, 2001
- Widespread Integration and Survival of Adult-Derived Neural Progenitor Cells in the Developing Optic RetinaMolecular and Cellular Neuroscience, 1998