Impaired IgM antibody responses to an influenza virus vaccine in adults with sickle cell anemia

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Abstract
Type‐specific IgM and IgG antibody responses to a polyvalent influenza vaccine were evaluated in 16 adults with sickle cell anemia, with the use of an enzyme‐linked immunosorbent assay. When compared to healthy controls, 8 out of the 16 patients had decreased or undetectable postvaccination anti‐influenza IgM antibody levels. These patients were found to have significantly lower serum IgM levels and nondetectable splenic tissue (by 99Tc scans), as compared to those with normal IgM responses. Impaired IgM antibody primary immune responses may playa role in the pathogenesis of infectious complications seen in adult patients with sickle cell anemia.