Early Plasma Cell Recruitment In Multiple Myeloma Following Chemotherapy

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Abstract
Therapy‐induced modifications of bone marrow plasma cell kinetics were studied in three patients with myelomatosis. the investigation was performed prior to and 15 d after termination of a course of aggressive chemotherapy. an increase in the labelling index (40‐212% of pretreatment values) with a corresponding reduction of Ts (5‐34%) was observed in all cases. As a consequence of this combined variation, the fractional turnover rate (which represents the percentage of cells produced per unit time) was the parameter with the highest increment (54‐276%). These results indicate that plasma cell recruitment occurs soon after chemotherapy and is characterized by a shorter S phase and a higher number of DNA‐synthesizing cells.