FALL OF PLASMA OSMOLALITY CREATED AT DIALYZER AND ITS POSSIBLE EFFECT ON CIRCULATING BLOOD-VOLUME

  • 1 January 1979
    • journal article
    • research article
    • Vol. 12  (6) , 269-272
Abstract
A mathematical analysis of fluid exchange during hemodialysis therapy was performed to determine which factors affect the circulating blood volume and hence the circulatory stability. Both fluid removal and the fall of plasma osmolality during the passage of blood through the dialyzer can affect the circulating blood volume profoundly. The latter accelerated the decrease of circulating blood volume by an indirect action on capillary refilling. Some treatment systems such as those involving recirculation or ultrafiltration show a small drop in osmolality with a correspondingly small drop in blood pressure. This result is compatible with clinical experiences reported earlier and may explain why some methods of treatment are accompanied by stable circulatory function in spite of rapid removal of large amounts of fluid.

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