Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, rough
- 1 July 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 334 (6178) , 151-154
- https://doi.org/10.1038/334151a0
Abstract
Homoeo-box genes play a central role in the regulation of embryogenesis in Drosophila melanogaster. Their widespread phylogenetic distribution, and the tissue and stage specificity of their expression in other organisms, argue that they play a general and significant role in animal development. In D. melanogaster, all homoeo-box genes characterized to date are involved in major aspects of embryogenesis. We report here the molecular characterization of a Drosophila homoeo-box gene that has no apparent involvement in early embryogenesis. The gene appears to be rough, a gene implicated in pattern formation in the developing eye. It is expressed in cells within, and posterior to, the morphogenetic furrow, the site of the primary pattern forming events in the developing retina, and also in a region of the brain of the third instar larva. We have found no genetic or molecular evidence of a role for this gene in other aspects of fly developmentKeywords
This publication has 30 references indexed in Scilit:
- Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene networkCell, 1986
- Isolation, structure, and expression of even-skipped: A second pair-rule gene of Drosophila containing a homeo boxCell, 1986
- Transcripts encoded by a homoeo box gene are restricted to dorsal tissues of Drosophila embryosNature, 1986
- Phylogenetic distribution of Antennapedia-like homoeo boxesNature, 1986
- Spatial restriction in expression of a mouse homoeo box locus within the central nervous systemNature, 1986
- Homeo Box Sequences of the Antennapedia Class Are Conserved Only in Higher Animal GenomesPublished by Cold Spring Harbor Laboratory ,1985
- Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcriptsNature, 1985
- Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.Proceedings of the National Academy of Sciences, 1984
- A homologous protein-coding sequence in drosophila homeotic genes and its conservation in other metazoansCell, 1984
- A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexesNature, 1984