Elderly Patients with Advanced Non-Small Cell Lung Cancer

Publisher Website
Google Scholar
Abstract
Objectives: The incidence of non-small cell lung cancer (NSCLC) is increasing among the elderly. We studied the toxicity and efficacy of a weekly schedule of gemcitabine and cisplatin in elderly patients with advanced NSCLC. Methods: Patients aged 70 years or above with advanced NSCLC were treated in a phase II prospective trial with gemcitabine 1,000 mg/m2 and cisplatin 35 mg/m2 on days 1, 8 and 15 every 28 days. Results: Forty-eight patients with a median age of 74 years (range 70–78) participated in the study. We observed 14 cases with partial response, 14 with stable disease and 16 with progressive disease, whilst 4 patients were not evaluable. By intention-to-treat analysis, partial response rate was 31.8% whilst progressive disease was 33.3%. Median survival was 9 months; 1-year survival probability was 34.4% and median time to progression was 4 months. Grade III–IV leukopenia was observed in 5/48 patients (10.4%), 20/48 patients (41.7%) had grade III–IV thrombocytopenia and 7/48 patients (14.6%) had grade III–IV anemia. One patient experienced grade III emesis and 2 patients had grade III–IV fatigue. Conclusions: At this dose and schedule the combination of gemcitabine and cisplatin appears to be an active and well-tolerated regimen for elderly patients with advanced NSCLC.