Morbidity and Mortality Associated With Nosocomial Transmission of Oseltamivir- Resistant Influenza A(H1N1) Virus
Open Access
- 11 March 2009
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 301 (10) , 1042-1046
- https://doi.org/10.1001/jama.2009.297
Abstract
A global emergence and rapid spread of oseltamivir-resistant influenza A(H1N1) viruses carrying a neuraminidase (NA) gene with an H274Y (N2 numbering; H275Y in N1 numbering) amino acid substitution has been observed since January 2008.1-3 Viruses carrying this mutation are presumed to exhibit attenuated pathogenicity,4 compromised transmission,5 and reduced lethality.6 However, current widespread circulation of oseltamivir-resistant influenza A(H1N1) viruses associated with typical influenza illnesses and viral pneumonia suggest that these viruses retain significant transmissibility and pathogenicity.2,3,7,8 While these resistant variants may cause significant mortality and retain efficient transmission, these properties have not yet been firmly established.Keywords
This publication has 8 references indexed in Scilit:
- Developing New Antiviral Agents for Influenza Treatment: What Does the Future Hold?Clinical Infectious Diseases, 2009
- Fatal Oseltamivir-Resistant Influenza Virus InfectionNew England Journal of Medicine, 2008
- Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in EuropeEurosurveillance, 2008
- Severe influenza resembling hemorrhagic shock and encephalopathy syndromeJournal of Clinical Virology, 2007
- Influenza Viruses Resistant to the Antiviral Drug Oseltamivir: Transmission Studies in FerretsThe Journal of Infectious Diseases, 2004
- Rapid and Sensitive Method Using Multiplex Real-Time PCR for Diagnosis of Infections by Influenza A and Influenza B Viruses, Respiratory Syncytial Virus, and Parainfluenza Viruses 1, 2, 3, and 4Journal of Clinical Microbiology, 2004
- The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivoAntiviral Research, 2002
- Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-d-N-acetylneuraminate) substrateAnalytical Biochemistry, 1979