Inhibitory Effect of a New Synthetic Protease Inhibitor (FUT-175) on the Coagulation System
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 15 (3) , 164-168
- https://doi.org/10.1159/000215139
Abstract
The inhibitory effects of 6-amidino-2-naphthyl-4-guanidinobenzoate .cntdot. dimethanesulfonate (FUT-175) on the human Hageman factor fragment (HFf), factor Xa, thrombin, plasma kallikrein, and plasmin were studied. FUT-175 inhibited plasma kallikrein most (IC50 [concentration producing 50% inhibition] = 3.0 .times. 10-9 M), followed by HFf (IC50 = 3.3 .times. 10-7 M). FUT-175 had an anticoagulant effect in the APTT [activated partial thromboplastin time] and PT [prothrombin time] assay systems of human plasma. The concentration of FUT-175 for 2-fold increase in the clotting time in the APTT assay system was 5 .times. 10-7 M.This publication has 8 references indexed in Scilit:
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