BACILLUS CALMETTE-GUERIN AND DINITROCHLOROBENZENE IMMUNOTHERAPY OF CHEMICALLY-INDUCED BLADDER TUMORS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 14  (5) , 369-372
Abstract
Immunologic incompetence is corrrelated with increased susceptibility to malignancy. Immunostimulation with such agents as BCG and dinitrochlorobenzene (DNCB) resulted in regression of cutaneous malignancies. An evaluation of the effect of BCG and DNCB sensitization and bladder irrigation in Fischer rats revealed no decrease in the incidence of bladder tumors induced by 2-formylamino-4-(5-nitro-2-furyl)thiazole (FANFT). Direct intralesional injection of BCG into early bladder tumors was effective in preventing the progression of such tumors in 7 of 10 BCG-sensitized rats (P < 0.005). No effect was seen when BCG was injected intralesionally in unsensitized rats or when control solutions were injected.

This publication has 2 references indexed in Scilit: