Computer modelling of radiation-induced bystander effect
- 1 September 2002
- journal article
- Published by IOP Publishing in Journal of Radiological Protection
- Vol. 22 (3) , A33-A37
- https://doi.org/10.1088/0952-4746/22/3a/306
Abstract
Radiation-induced genomic instability and bystander effects are now well established consequences of exposure of living cells to ionising radiation. It has been observed that cells not directly hit by radiation tracks may still exhibit radiation effects. We present a quantitative modelling of the radiation-induced bystander effect based on a diffusion model of spreading the bystander signal. The model assumes the bystander factor to be aprotein of low molecular weight, given out by the hit cell, diffusing in the medium and reacting with non-hit cells. The model calculations successfully predict the results of cell survival in an irradiated conditioned medium. The model predicts the shape of dose-effect relationship for cell survival and oncogenic transformation induced by broad-beam and micro-beam irradiation by alpha-particles.Keywords
This publication has 11 references indexed in Scilit:
- Radiation-Induced Bystander Effects: Past History and Future DirectionsRadiation Research, 2001
- The Bystander Effect in Radiation Oncogenesis: II. A Quantitative ModelRadiation Research, 2001
- The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated CellsRadiation Research, 2001
- Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancerMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000
- The oncogenic transforming potential of the passage of single α particles through mammalian cell nucleiProceedings of the National Academy of Sciences, 1999
- Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha ParticlesRadiation Research, 1998
- Cell-Cell Contact during Gamma Irradiation Is Not Required to Induce a Bystander Effect in Normal Human Keratinocytes: Evidence for Release during Irradiation of a Signal Controlling Survival into the MediumRadiation Research, 1998
- Studies of bystander effects in human fibroblasts using a charged particle microbeamInternational Journal of Radiation Biology, 1998
- Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cellsInternational Journal of Radiation Biology, 1997
- The translational mobility of substances within the cytoplasmic matrix.Proceedings of the National Academy of Sciences, 1984