Efficient stereoselective synthesis of natural α-tocopherol (vitamin E)
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 995-997
- https://doi.org/10.1039/c39790000995
Abstract
Reduction by bakers' yeast of the aldehyde (1) gives 2-methyl-5-phenylpent-4-en-1-ol, containing ca. 87% of the (2S)-isomer (3), which is converted into (3R,7R)-3,7,11-trimethyldodecan-1-ol (8), a key intermediate in the synthesis of natural α-tocopherol (19); the same alcohol (8) and its lower homologue (16), which is also an intermediate in the same synthesis, are both obtained in optically pure form from the acid (9).Keywords
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