Pneumococcal vaccination in children with acute lymphocytic leukemia

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Abstract
Sixty‐three children with ALL in CCR and treated according to a standard therapy protocol were immunized with the 14‐valent pneumococcal vaccine. Forty‐six children were vaccinated 1, 3, or 6 months following initial induction remission; 15 were vaccinated 4–6 weeks following successful completion of 30 months of antileukemia therapy; and two were vaccinated at the time of diagnosis. Response to the vaccine was suboptimal and by the 6‐month follow‐up there were only two serotypes for which more than half the patients tested had > 300 ng antibodies N/ml.