Conformationally constrained inhibitors of caspase-1 (interleukin-1β converting enzyme) and of the human ced-3 homologue caspase-3 (CPP32, apopain)
- 6 October 1998
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 8 (19) , 2757-2762
- https://doi.org/10.1016/s0960-894x(98)00498-3
Abstract
No abstract availableKeywords
This publication has 29 references indexed in Scilit:
- Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzymeBioorganic & Medicinal Chemistry Letters, 1997
- PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE)Bioorganic & Medicinal Chemistry Letters, 1997
- First Examples of Peptidomimetic Inhibitors of Interleukin-1β Converting EnzymeJournal of Medicinal Chemistry, 1996
- Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting EnzymeScience, 1995
- Aspartyl .alpha.-((1-Phenyl-3-(trifluoromethyl)- pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1.beta. Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme-Peptide Inhibitor BindingJournal of Medicinal Chemistry, 1994
- The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.Bioorganic & Medicinal Chemistry Letters, 1994
- Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin‐l β converting enzyme (ICE)International Journal of Peptide and Protein Research, 1994
- Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger LactamsJournal of the American Chemical Society, 1994
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzymeCell, 1993
- A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytesNature, 1992