Facile Synthesis of α-Keto Esters via A Free Radical Acylation Approach
- 1 June 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1997 (Sup. I) , 475-476
- https://doi.org/10.1055/s-1997-6143
Abstract
A new efficient method for the preparation of α-keto esters via a free radical acylation approach using phenylsulfonyl methoxycarbonyl oxime ether 1 has been developed. When an alkyl iodide was treated with 1, hexamethylditin, and acetone in THF at 300 nm for 3 h, α-keto ester 3 was obtained in high yield after hydrolysis of the oxime ether 2.Keywords
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