Sensitivity and Specificity of Quantitative Determination of Pancreatic Elastase 1 in Feces of Children

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Abstract
Background: The secretin-pancreozymin test has been accepted as the gold standard for testing exocrine pancreatic function. However, this test is invasive, time-consuming, and expensive. Therefore, in daily practice, more simple, indirect methods are proposed. Methods: The fecal concentration of human pancreatic elastase (E1) has been assessed for diagnostic sensitivity and specificity. For sensitivity, fecal E1 determination in 23 healthy children were studied. Results: Sensitivity to detect pancreatic insufficiency was 100% and specificity 96%. Conclusions: Fecal E1 concentration appears to be a more sensitive and specific test of pancreatic function than other tests.

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