AN ATTEMPT TO DEMONSTRATE ANTIBODIES IN ECZEMATOUS CONTACT-TYPE DERMATITIS
- 1 February 1952
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Dermatology and Syphilology
- Vol. 65 (2) , 149-154
- https://doi.org/10.1001/archderm.1952.01530210028004
Abstract
THE SEARCH for antibodies in eczematous contact dermatitis has extended principally in three directions: demonstration of the tissue of origin, establishment of a time-route relationship between local and generalization of sensitization, and identification of the antibodies. Sulzberger1and Landsteiner2suggested that sensitivity probably originates in the epidermis, although Landsteiner felt that the introduction of allergen on or into the skin was not mandatory. Haxthausen3concluded that antibodies are produced by the epidermis. By surgical circumvallation of skin islands Landsteiner and Chase4and Rostenberg5indicated that a substance, probably antigen or antibody emanating from the skin, was absorbed via the lymphatics. In guinea pigs Landsteiner and Chase6passively transmitted generalized sensitivity by lymphocytes. Haxthausen7confirmed these results but was unable to demonstrate local passive transmission by lymphocytes in guinea pigs or in man. Sensitizing antibodies demonstrable by passive transfer have beenKeywords
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