v-src inhibits differentiation via an extracellular intermediate(s).
Open Access
- 1 October 1985
- journal article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 5 (10) , 2847-2850
- https://doi.org/10.1128/mcb.5.10.2847
Abstract
Murine 3T3L1 preadipocytes transformed by avian sarcoma virus were unable to differentiate in response to insulin or dexamethasone plus 1-methyl-3-isobutylxanthine, both potent inducers of differentiation of the nontransformed 3T3L1 parental line. Conditioned medium from transformed cells contained a relatively heat-stable factor(s) which inhibited the differentiation of untransformed parental 3T3L1 cells but did not induce any changes in their morphology. A protease-sensitive mitogen was also detected in the medium. The relationship between the two activities remains to be elucidated.Keywords
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