Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer
Open Access
- 18 August 2004
- journal article
- review article
- Published by Wiley
- Vol. 574 (1-3) , 1-8
- https://doi.org/10.1016/j.febslet.2004.08.013
Abstract
The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their post‐translational modifications, such as phosphorylation, acetylation and methylation, are discussed and suggested as suitable targets for cancer chemotherapy.Keywords
This publication has 72 references indexed in Scilit:
- Differential regulation of the insulin‐like growth factor II mRNA‐binding protein genes by architectural transcription factor HMGA2FEBS Letters, 2004
- Recruitment of SWI/SNF to the Human Immunodeficiency Virus Type 1 PromoterMolecular and Cellular Biology, 2004
- High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: its potential use in the diagnosis of liver neoplasmsThe Esophagus, 2003
- PU.1-mediated Transcription Is Enhanced by HMG-I(Y)-dependent Structural MechanismsPublished by Elsevier ,2001
- Phosphorylation of HMG‐I by Protein Kinase C Attenuates Its Binding Affinity to the Promoter Regions of Protein Kinase C γ and Neurogranin/RC3 GenesJournal of Neurochemistry, 2000
- A Small Region in HMG I(Y) Is Critical for Cooperation with NF-κB on DNAJournal of Biological Chemistry, 1999
- Enhancement of Serum-response Factor-dependent Transcription and DNA Binding by the Architectural Transcription Factor HMG-I(Y)Published by Elsevier ,1998
- Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different proceduresExperimental Cell Research, 1989
- Fractionation by high-performance liquid chromatography of the low-molecular-mass high-mobility-group (HMG) chromosomal proteins present in proliferating rat cells and an investigation of the HMG proteins present in virus transformed cellsEuropean Journal of Biochemistry, 1985
- On the presence of two new high mobility group‐like proteins in HeLa S3 cellsFEBS Letters, 1983