Treatment of intestinal microsporidiosis with albendazole in patients with AIDS

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Abstract
Objective To determine the clinical and parastilogical repsonse to treatment of intestinal microsporidiosis with albendazole. Design Open prospective study. Setting Hospital-based HIV/genito-urinary medicine unit. Patients, participants Six consecutive AIDS patients with small intestianl microsporidiosis as the only identified cause of diarrhoea after intensive gastrointestinal investigations. Results Diarrhoea resolved completely in all patients within 1 week of starting treatment, and body weight stabilized or increased. Four patients who relapsed at 19–31 days after the cessation of treatment responded to a second course of albendazole. Degenerative changes occurred in the parasites after treatment, which had not been seen either in pre-treatment biopsies or, in four patients, following therapy with other drugs. Conclusions Albenazole is a useful palliative treatment for microsporidial diarrhoea.

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