Sterol synthesis after whole body roentgen irradiation

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Abstract
Male rats were given 400 r whole body irradiation. The in vivo incorporation of 2-Cl4-acetate in liver cholesterol decreased during the first day after irradiation and subsequently increased. The hepatic cholesterol concentration fell immediately, rose above normal and slowly fell again. Histologic studies showed no change in cell population. Total radioactivity incorporated in liver tissue, as shown by auto-radiographs reached a maximum 1 day after irradiation. Incubation of rat liver slices with 2-C14-acetate showed an increase in the metabolism of acetate to carbon dioxide, and an initial increase followed by a fall in the synthesis of digitonine-precipitable sterols from acetate.

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