Reaction of Blood Pressure and Mesenteric Blood Flow to Infusion of Biogenic Amines in Normal and Supralethally X-Irradiated Rats

Publisher Website
Google Scholar
Abstract
The responses of blood pressure and mesenteric blood flow were recorded during infusion of biogenic amines (noradrenaline [norepinephrine], dopamine, serotonin, acetylcholine and histamine) to control and X-irradiated rats (1st and 3rd days after 2 kR X-irradiation). Responses to different doses of the amines were evaluated. The responses corresponded to those in other species (e.g., an increase in pressure and a decrease in flow with an overshoot after infusion of norepinephrine, an increase in pressure and flow after dopamine, an increase in pressure and a decrease in flow after serotonin, a decrease in pressure and flow after acetylcholine, and a decrease in pressure and an increase in flow after histamine). Irradiated animals are more responsive to pressure-raising agents, in particular to norepinephrine. They have an altered dose-pressure response curve for dopamine.

This publication has 0 references indexed in Scilit: