Electrospray mass spectrometry in the differentiation of some isomeric trimethylfurocoumarins
- 17 November 2003
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 17 (24) , 2781-2787
- https://doi.org/10.1002/rcm.1260
Abstract
Electrospray mass spectrometry (ES‐MS) was successfully employed for the structural differentiation of six isomeric trimethylfurocoumarins of possible pharmaceutical interest. Two different approaches were employed. The first was based on MSn experiments of MH+ ions. Although the product ion spectra of MH+ of the isomers are very similar, the MS3 spectra of the collisionally generated [MHCO]+ ions show some characteristic differences. The second approach was based on complexation of the molecules with Li+, Na+ and K+ using ESI‐MS of sample solutions containing alkali ions in a 100:1 molar ratio with respect to the analyte. Significant differences were observed in complex production yields, and these were related to the dimension of the alkali ion and to the steric availability of chelating groups in the different isomers. Copyright © 2003 John Wiley & Sons, Ltd.Keywords
This publication has 22 references indexed in Scilit:
- Photoinduction of micronuclei by 4,4′,6-trimethylangelicin and 8-methoxypsoralen in different experimental modelsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1995
- Mass spectrometric studies of selected coumarins and psoralens. I—negative ionsJournal of Mass Spectrometry, 1993
- A study of relevant parameters in collisional‐activation of ions in the ion‐trap mass spectrometerRapid Communications in Mass Spectrometry, 1990
- Characterization of isomeric pyranocoumarins by collision‐induced tandem mass spectrometryRapid Communications in Mass Spectrometry, 1990
- Collisional spectroscopy potentialities in structural characterization of variously annulated furanocoumarinsJournal of Mass Spectrometry, 1986
- 1H NMR spectra of variously annulated furocoumarinsMagnetic Resonance in Chemistry, 1985
- On chemical form of Na+ ion in aqueous solutionsCollection of Czechoslovak Chemical Communications, 1983
- Crystal structures of sodium sulfate decahydrate (Glauber's salt) and sodium tetraborate decahydrate (borax). Redetermination by neutron diffractionActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1978
- Structure cristalline de dérivés d'acides aminés. II. Le composé d'addition LiBr.L-alanylglycine.2H2OActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1971
- Crystal Structure and Entropy of Sodium Sulfate DecahydrateJournal of the American Chemical Society, 1961