Renal cell carcinoma metastatic to the thyroid gland: A comparative molecular study between the primary and the metastatic tumor
- 1 September 1998
- journal article
- research article
- Published by Springer Nature in Endocrine Pathology
- Vol. 9 (3) , 255-260
- https://doi.org/10.1007/bf02739966
Abstract
A case of renal cell carcinoma metastatic to the thyroid gland is presented. The thyroid tumor showed typical features: clear cells arranged in nets with a prominent sinusoidal vascular pattern. The histologic appearance was identical to the renal tumor removed 6 yr before. A comparative molecular study between the primary and the metastatic tumor showed a common profile with a loss of heterozygosity at identical loci on chromosome 3, which provided further support to the metastatic nature of the thyroid tumor. However, the frequent existence of allele losses on chromosome 3p in both renal cell carcinomas and primary thyroid follicular carcinomas rest some force from such a molecular approach to the differential diagnosis of thyroid tumors that contain a predominant population of clear cells.Keywords
This publication has 12 references indexed in Scilit:
- Major role for a 3p21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysisGenes, Chromosomes and Cancer, 1996
- Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.1994
- Somatic mutations of the von Hippel — Lindau disease tumour suppressor gene in non-familial clear cell renal carcinomaHuman Molecular Genetics, 1994
- Mutations of the VHL tumour suppressor gene in renal carcinomaNature Genetics, 1994
- Loss of heterozygosity at the short arm of chromosome 3 in renal‐cell cancer correlates with the cytological tumour typeInternational Journal of Cancer, 1993
- Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.Journal of Clinical Investigation, 1991
- A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma.1991
- Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinomaNature, 1987
- Clear cell change in primary thyroid tumorsThe American Journal of Surgical Pathology, 1985
- Clear cell renal carcinoma masquerading as thyroid enlargementThe Journal of Pathology, 1974