The effect of age on insulin-degrading activity in rat tissue
- 1 April 1979
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 28 (4) , 324-325
- https://doi.org/10.2337/diabetes.28.4.324
Abstract
Insulin-degrading activity was measured in the 100,000g supernatant fraction of muscle, liver, and kidney from rats of varying ages. Young animals (four weeks old) had the highest activity in all three tissues. By seven weeks of age the activity in both muscle and liver had decreased significantly as compared with four-week-old animals. A slight but nonsignificant decrease occurred in kidney. In animals over one year of age the insulin-degrading activity in all three tissues was significantly less than the activities at either four or seven weeks. In contrast the effect of age on degradation of albumin and parathormone was much less marked.This publication has 7 references indexed in Scilit:
- Effect of Age and Weight on Plasma Glucose and Insulin Responses in the Rat†Journal of the American Geriatrics Society, 1977
- Insulin TodayDiabetes, 1977
- Insulin and glucagon degradation by the kidney II. Characterization of the mechanisms at neutral pHBiochimica et Biophysica Acta (BBA) - General Subjects, 1976
- Insulin and glucagon degradation by the kidney I. Subcellular distribution under different assay conditionsBiochimica et Biophysica Acta (BBA) - General Subjects, 1976
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- EFFECT OF AGE ON PLASMA PROINSULIN-LIKE MATERIAL AFTER ORAL GLUCOSE1976
- Carbohydrate Tolerance and Diabetes in a Total Community, Tecumseh, Michigan: 1. Effects of Age, Sex, and Test Conditions on One-hour Glucose Tolerance in AdultsDiabetes, 1965