Relation of renal gluconeogenesis to ammonia production in the dog and rat

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Abstract
The role of renal gluconeogenesis in the adaptive increase in ammonia production during metabolic acidosis was studied in dogs and rats. Administration of ammonium chloride from 1 to 3 weeks to rats and dogs stimulated gluconeogenesis as evidenced by increased glucose production from either succinate or glutamine in kidney slices, whereas sodium bicarbonate administered for a similar period depressed gluconeogenesis. Chronic respiratory acidosis had no effect on either gluconeogenesis or ammonia excretion. The enhanced gluconeogenesis during metabolic acidosis was not attributable to inhibition of the Krebs cycle since the conversion of acetate-2-14c to 14CO2 by rat kidney slices was unimpaired.