Skin carcinogenesis and promoter binding characteristics in different mouse strains

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Abstract
The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics of the tumour promoter [ 3 H]phorbol-12,13-di-butyrate to particulate skin preparations. The mouse strains tested were Swiss albino, Balb/c, C 3 H, LACA and AKR/J. Although some differences were apparent, Swiss albino, LACA and C 3 H mice were generally sensitive to skin carcinogenesis by both benzo[a]pyrene and 7,12-dimethylbenz[a]-anthracene, either with or without promotion with croton oil. AKR/J mice were sensitive to both carcinogens with promotion but relatively insensitive in the absence of promotion. Balb/c mice had low sensitivity except when exposed to repeated low doses of benzo[a]pyrene. The [ 3 H]phorbol-12,13-dlbutyrate binding characteristics of particulate skin preparations from all strains were indistinguishable.