L-asparaginase-induced coagulopathy during therapy of acute lymphocytic leukemia

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Abstract
L-Asparaginase-induced coagulation abnormalities were observed in all patients receiving this drug. All patients studied demonstrated low factor IX and fibrinogen levels and most (75%) had low levels of factor XI. Disturbances in other factors were much less frequent. Despite the presence of markedly abnormal coagulation studies, clinical bleeding was not observed.