Persisting Effects of Reserpine in Man

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Abstract
ALTHOUGH reserpine is widely used in psychiatric and medical practice, the rates of recovery from the effects of the drug on blood serotonin and on autonomie functions have not been extensively delineated in man. This report describes the recovery curves of blood serotonin and pupil size in man after single large doses of reserpine. In animals, effects on blood and brain serotonin and on autonomie functions (bradycardia, ptosis and miosis) persist for a number of days after withdrawal of the drug.1 2 3 4 5 6 Such studies have to some extent elucidated the basis for persisting effects of the drug.Reserpine induces a release . . .