A Novel Fusion Gene, SYT-SSX4, in Synovial Sarcoma
Open Access
- 2 June 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 91 (11) , 974-975
- https://doi.org/10.1093/jnci/91.11.974
Abstract
Cloning of the translocation t(X;18) (p11.2;q11.2) from human synovial sarcoma revealed a fusion between the SYT gene, also known as SSXT, located on chromosome 18 and the SSX gene located on the X chromosome ( 1 ). Five variants of the SSX gene (SSX1, SSX2, SSX3, SSX4, and SSX5) have been identified ( 2 ) but, to date, only SSX1 and SSX2 have been shown to fuse with the SYT gene in the translocation t(X;18) in synovial sarcoma ( 3 , 4 ).Keywords
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