RELATIONSHIP BETWEEN PLASMA-LEVELS OF FACTOR-VIII RELATED ANTIGEN AND RETICULOENDOTHELIAL FUNCTION IN CHRONIC UREMIA

  • 1 January 1983
    • journal article
    • research article
    • Vol. 20  (5) , 235-238
Abstract
The plasma levels of factor VIII related antigen (F VIIIR:Ag; determined by rocket electrophoresis) and reticuloendothelial function (measured by means of the removal kinetics of human albumin millimicrospheres) were studied in a group of patients with chronic renal failure. F VIIIR:Ag plasma levels were increased, median 304% (interquartile ranges 211-433%) compared to the controls, median 112% (interquartile ranges 100-144%; P < 0.01). Reticuloendothelial function was decreased, median 8.3 .mu.g/min per kg body wt (interquartile ranges 6.2-10.1 .mu.g/min body wt) compared to the controls, median 15.0 .mu.g/min per kg body wt (interquartile ranges 11.9-19.0 .mu.g/min per kg body wt; P < 0.02). A significant inverse relationship was found between plasma levels of F VIIIR:Ag and the reticuloendothelial function rs = 0.075; P < 0.01). As the main site of catabolism of F VIIIR:Ag is the reticuloendothelial system, the impairment of its function may be a possible explanation for the elevated plasma levels of the F VIIIR:Ag found in patients with end stage renal disease.