Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
- 25 August 1990
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 81 (8) , 738-741
- https://doi.org/10.1111/j.1349-7006.1990.tb02638.x
Abstract
The three-day-old larvae of self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus were fed a diet containing the antioxidant butylated hydroxyanisole (BHA) at levels of 0.01-0.8% for 12 days. Six months after BHA administration, hepatic tumors were found in all groups of BHA-treated fish. The BHA-induced tumor incidences were clearly dose-dependent. These results show that dietary BHA is hepatocarcinogenic in Rivulus even at 0.01% dose.Keywords
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