Immunization with RecombinantPlasmodium yoeliiMerozoite Surface Protein 4/5 Protects Mice against Lethal Challenge

Open Access

1 October 2000

journal article
Published by American Society for Microbiology in Infection and Immunity

Vol. 68 (10) , 6034-6037
https://doi.org/10.1128/iai.68.10.6034-6037.2000

Abstract

Plasmodium yoeliimerozoite surface protein 4/5 (PyMSP4/5), expressed as a recombinant protein, was highly effective at protecting mice against lethal challenge withP. yoelii. There was a significant correlation between prechallenge antibody levels and peak parasitemia, suggesting that the homologues of PyMSP4/5 inPlasmodium falciparumare promising components of a subunit vaccine against malaria.

Keywords

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