Renal gluconeogenesis, adenine nucleotides, and enzyme activities
- 1 November 1968
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 46 (11) , 1345-1349
- https://doi.org/10.1139/o68-204
Abstract
Various drugs which alter rates of glucose production by rat kidney slices from pyruvate or other substrates were found to have marked effects on the relative contents of ATP, ADP, and AMP in the kidney slices. The effects of the changes in adenine nucleotide concentrations on the activity of key enzymes concerned with glycolysis and gluconeogenesis were investigated. The results generally support the concept that the drugs affect gluconeogenesis secondarily by altering the concentrations of the adenine nucleotides in the tissue.Keywords
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