CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914

This publication has 33 references indexed in Scilit:

• Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist
  Journal of Medicinal Chemistry, 2000
• The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding
  Molecular and Cellular Biology, 2000
• Transcriptional regulation of the glycoprotein hormone α-subunit gene by pituitary adenylate cyclase-activating polypeptide (PACAP) in αT3-1 cells
  Molecular and Cellular Endocrinology, 1998
• RU486 (MIFEPRISTONE): Mechanisms of Action and Clinical Uses
  Annual Review of Medicine, 1997
• RU486
  Current Opinion in Obstetrics and Gynecology, 1994
• The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.
  Proceedings of the National Academy of Sciences, 1993
• Characterization and Functional Properties of the A and B Forms of Human Progesterone Receptors Synthesized in a Baculovirus System
  Molecular Endocrinology, 1991
• Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes
  Experimental Cell Research, 1987
• Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids
  The Journal of Steroid Biochemistry and Molecular Biology, 1986
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
  Analytical Biochemistry, 1976