Separation of Legionella pneumophila Proteases and Purification of a Protease Which Produces Lesions Like Those of Legionnaires" Disease in Guinea Pig Lung

Publisher Website
Google Scholar
Abstract
Six discrete protease activities were recovered from the supernatant broth of Legionella pneumonphila cultures by ion-exchange chromatography. One of these demonstrated in vitro activity against collagen, casein and gelatin. When administered into the lungs of guinea-pigs this protease elicited lesions which were pathologically similar to those seen in clinical and experimentally induced Legionnaires'' disease.