Compared myocardial and vascular effects of captopril and dihydralazine during hypertension development in spontaneously hypertensive rats

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Abstract
When administered to young spontaneously hypertensive rats (SHR), dihydralazine (25 mg/kg, daily) and captopril (100 mg/kg, daily), prevent with the same efficacy genetic hypertension development (GHD). Dihydralazine treatment increased vascular mesenteric compliance, as shown by a significant decrease in the stiffness of the vessels (-27%), and induced slight reductions in contractility (-12%) and in wall to lumen (W/L) ratio (-15%). After treatment withdrawal, all these parameters returned to control values within 7 wk, as did blood pressure. Captopril treatment also strongly increased the mesenteric vessels compliance, vessel stiffness being decreased by 16%, and reduced their contractility (-15%) and their W/L ratio (-30%). These effects as well as those exerted on blood pressure persisted up to 7 wk after treatment ceased although there was a slight trend to a progressive reduction in the intensity of both phenomena. Evidently, captopril but not dihydralazine has a long-lasting effect in opposing the functional and morphological vascular alterations occurring during GHD in SHR and this phenomenon probably contributes to a large extent of the sustained preventive effects of the drug against GHD.