Instability of CHO chromosomes containing interstitial telomeric sequences originating from Chinese hamster chromosome 10
- 1 January 1997
- journal article
- animal cytogenetics-and-comparative-mapping
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 76 (1-2) , 58-60
- https://doi.org/10.1159/000134516
Abstract
We identified a marker chromosome in the CHO K1 cell line containing amplifications of interstitial telomeric sequences originating from Chinese hamster chromosome 10. Analysis of the progression of this chromosome in two sub-clones of CHO K1 revealed sensitivity of one amplicon to chromosome breakage, resulting in telomere function at the break site. In addition, two more marker chromosomes, both containing amplifications of interstitial telomeric sequences from chromosome 10, were formed during karyotypic evolution of the CHO K1 subclones. The presence of some of the marker chromosomes was also identified in the radiosensitive xrs 5 cell line derived from CHO K1. These results indicate instability of CHO K1 chromosomes containing interstitial telomeric sequences originating from Chinese hamster chromosome 10.Keywords
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