THE ACTIVITY OF PARTIALLY PURIFIED LEUKOCYTIC ENDOGENOUS MEDIATOR IN ENDOTOXIN-RESISTANT C3H-HEJ MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 95  (4) , 616-623
Abstract
Partially purified LEM [leukocytic endogenous mediator] was injected into the endotoxin[etox]-resistant C3H/HeJ and the closely related, but etox-responsive, C3Heb/FeJ strains of mice. Both strains of mice responded to LEM with significant decreases in plasma Fe concentration, increased number of peripheral blood neutrophils, increased plasma levels of CSA [colony stimulating activity] and elevations of plasma fibrinogen concentration. Injections of [Escherichia coli or Salmonella abortus] etox produced significant responses in these 4 determinations in C3Heb/FeJ mice but had no effect in the C3H/HeJ strain. Changes in plasma Fe, fibrinogen, CSA and neutrophils may occur when LEM is produced by an interaction of etox with phagocytic cells.