The effect of stimulus pulse duration on selectivity of neural stimulation
- 1 January 1996
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Engineering
- Vol. 43 (2) , 161-166
- https://doi.org/10.1109/10.481985
Abstract
Choice of stimulus parameters is an important consideration in the design of neural prosthetic systems. The objective of this study was to determine the effect of rectangular stimulus pulsewidth (PW) on the selectivity of peripheral nerve stimulation. Computer simulations using a cable model of a mammalian myelinated nerve fiber indicated that shorter PW's increased the difference between the threshold currents of fibers lying at different distances from an electrode. Experimental measurements of joint torque generated by peripheral nerve stimulation demonstrated that shorter PW's generated larger torques before spillover and created a larger dynamic range of currents between threshold and spillover. Thus, shorter PW's allowed more spatially selective stimulation of nerve fibers. Analysis of the response of a passive cable model to different duration stimuli indicated that PW dependent contributions of distributed sources to membrane polarization accounted for the observed differences in selectivity.Keywords
This publication has 24 references indexed in Scilit:
- Current-distance relations of axons mediating circling elicited by midbrain stimulationPublished by Elsevier ,2003
- Non-invasive measurement of the input-output properties of peripheral nerve stimulating electrodesJournal of Neuroscience Methods, 1996
- The Role of Oxygen Reduction in Electrical Stimulation of Neural TissueJournal of the Electrochemical Society, 1994
- The Pulse‐Clamp Method for Analyzing the Electrochemistry on Neural Stimulating ElectrodesJournal of the Electrochemical Society, 1993
- Selective control of muscle activation with a multipolar nerve cuff electrodeIEEE Transactions on Biomedical Engineering, 1993
- Selective stimulation of peripheral nerve fibers using dual intrafascicular electrodesIEEE Transactions on Biomedical Engineering, 1993
- Muscle recruitment with intrafascicular electrodesIEEE Transactions on Biomedical Engineering, 1991
- Technology and Long-term Application of an Epineural ElectrodeAnnual Northeast Bioengineering Conference, 1989
- Recruitment data for nerve cuff electrodes: implications for design of implantable stimulatorsIEEE Transactions on Biomedical Engineering, 1989
- Which elements are excited in electrical stimulation of mammalian central nervous system: A reviewBrain Research, 1975