AN EFFICIENT METHOD FOR THE SYNTHESIS OF MACROCYCLIC LACTONE
- 5 April 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 6 (4) , 441-444
- https://doi.org/10.1246/cl.1977.441
Abstract
Long chain ω-hydroxycarboxylic acids were quantitatively converted to 6-phenyl-2-pyridyl esters by the treatment of the acids with 6-phenyl-2-pyridone and 2-chloro-1-methylpyridinium iodide in the presence of triethylamine. These esters were cyclized in refluxing methylene chloride by the promotion of p-toluenesulfonic acid to give macrocyclic lactones in high yields.Keywords
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