The Effect of Clindamycin on the Intestinal Flora in Patients with Enteric Hyperoxaluria

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Abstract
Because little is known about the composition of the intestinal flora in hyperoxaluric patients, 11 patients with hyperoxaluria (> 0.45 mmol/24 h) after jejunoileal bypass were studied under surgical ward conditions for 5 days. The patients were maintained on a constant diet. During days 3, 4 and 5, clindamycin (Dalacina), 1.8 g/24 h, was given parenterally in 3 divided doses. All patients had hyperoxaluria, with a mean oxalate absorption of 0.94 .+-. 0.09 mmol/24 h (.+-. standard error of the mean). No significant disturbances in the colonic microflora were found. The degree of hyperoxaluria did not change during clindamycin administration, in spite of a significant decrease in the number of anaerobic bacteria. Patients with enteric hyperoxaluria seemed to have a normal colonic microflora. The degree of hyperoxaluria did not seem to be related to changes in the intestinal anaerobic flora.