Pulmonary Alveolar Proteinosis
Top Cited Papers
- 25 December 2003
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 349 (26) , 2527-2539
- https://doi.org/10.1056/nejmra023226
Abstract
In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar macrophages require granulocyte–macrophage colony-stimulating factor (GM-CSF) to perform this function. Autoantibodies against GM-CSF may cause pulmonary alveolar proteinosis.Keywords
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