Determination of Some Penicillin Derivativies Using High Performance Liquid Chromatography
- 1 January 1984
- journal article
- pharmaceutical analysis
- Published by Taylor & Francis in Analytical Letters
- Vol. 17 (14) , 1659-1666
- https://doi.org/10.1080/00032718408065339
Abstract
A rapid, precise and selective method is described for determination of penicillin derivatives. Penicillin derivatives are separated from closely related degradation products by high performance liquid chromatography at ambient temperature using 10cm column packed with 5um Nucleosil RP18 and buffered aqueous acetonitrile as mobile phase. The eluate is monitored at 254nm. The procedure is suitable for determination of 8 penicillin derivatives either in raw material or phamaceutical dosage forms.Keywords
This publication has 1 reference indexed in Scilit:
- Separation of Penicillin G Potassium and its Degradation products using High-pressure Liquid ChromatographyJournal of Pharmaceutical Sciences, 1979