Dueling orphans–interacting nuclear receptors coordinate Drosophila metamorphosis
- 1 August 1997
- Vol. 19 (8) , 669-672
- https://doi.org/10.1002/bies.950190806
Abstract
At least seven orphan members of the nuclear receptor superfamily are transcriptionally regulated by the steroid hormone ecdysone and expressed during the onset of Drosophila metamorphosis. A recent paper provides functions for two of these receptors, E75B and DHR3, through trans‐regulation and heterodimerization(1). DHR3 appears to function as a switch that defines the transition from a late larva to a prepupa, and E75B functions as a timer that modulates this transition. This study provides a biological function for orphan receptor interactions during development.Keywords
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