Monoclonal Gammopathy Penicillamine-Induced Polymyositis and Systemic Sclerosis

1 August 1974

journal article
research article
Published by American Medical Association (AMA) in Archives of Dermatology

Vol. 110 (2) , 253-255
https://doi.org/10.1001/archderm.1974.01630080051014

Abstract

A 66-year-old Japanese man with systemic sclerosis had benign monoclonal gammopathy. Penicillamine therapy resulted in a hypersensitivity state, with marked eosinophilia. Later he developed polymyositis. Remission of the polymyositis and a decrease in the monoclonal immunoglobulin followed prednisolone therapy. Immunological disorders may play an important role in the pathogenesis of polymyositis.

Keywords

MONOCLONAL
PENICILLAMINE
SYSTEMIC
SCLEROSIS
GAMMOPATHY
POLYMYOSITIS
HYPERSENSITIVITY
JAPANESE
PREDNISOLONE
LATER