Parenteral fat emulsions and immune adherence. The effects of triglycerides on red cell and neutrophil immune adherence in vitro and in vivo

Publisher Website
Google Scholar
Abstract
Parenteral fat emulsions may not only exert nutritional effects but may also affect immune adherenece phenomena and red cell morphology. Red cell immune adherence (RCIA) was augmented in vitro by 0.05 to 0.1% intralipid. Similar augmentation of RCIA was observed by peanut oil, corn oil, half-and-half cream, paraffin oil and human low-density lipoprotein fractions. Neutrophil immune adherence was augmented in vitro by 0.2 to 1.5% of intralipid. The effects of fat emulsions in vivo were studied in 10 patients who received intralipid for nutritional purposes. Red cell immune adherence was augmented in 2- of 10 patients. Cytotoxic red cell transformations were evident in 5 of 10 patients. Depression of RCIA in 4 of 5 paients was associated with cytotoxic red cell transformations.

This publication has 1 reference indexed in Scilit: