X-ray Structure of Physiological Copper(II)−Bis(l-histidinato) Complex
- 1 May 2004
- journal article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 43 (11) , 3338-3340
- https://doi.org/10.1021/ic035413q
Abstract
The isolation and the X-ray crystal structure of physiological copper(II)−l-histidine complex are reported. The neutral five-coordinate complex shows distorted square pyramidal geometry with bidentate and tridentate l-histidine ligands. The basic character of the pendent imidazole group and H-bonding interactions of bidentate l-histidine ligand are important for copper transport. The unique structural features help explain the origin of its thermodynamic stability and kinetic reactivity in human blood along with the ternary copper(II)-amino acid complexes. The role of l-histidine in interaction with copper(II)−albumin, in cellular uptake of copper, and in treatment of Menkes disease can be studied using these results.Keywords
This publication has 30 references indexed in Scilit:
- Charge density in Cu(glygly)(OH2)2·H2O at 10 K and the reproducibility of atomic orbital populationsJ. Chem. Soc., Dalton Trans., 2001
- Copper transport and its alterations in Menkes and Wilson diseasesPublished by Elsevier ,2001
- Structural and Functional Aspects of Metal Sites in BiologyChemical Reviews, 1996
- Multifrequency ESR with Fourier analysis of copper(II)-(histidine)n. 2. Mobile phaseInorganic Chemistry, 1987
- Multifrequency ESR of copper(II)-(His)n (His = histidine). 1. Immobile phaseInorganic Chemistry, 1986
- Structural, motional, and kinetic features of the Cu(II)(l-His)2 complex in aqueous solutionJournal of Inorganic Biochemistry, 1985
- Electron spin resonance study of copper(II)–amino-acid complexes: evidence for cis and trans isomers and the structures of copper(II)–histidinate complexes in aqueous solutionJ. Chem. Soc., Dalton Trans., 1981
- Ternary Coordination Complexes Between Copper(II) and Amino Acids, and an Appraisal of the Enhancement of Ternary Complex StabilityCanadian Journal of Chemistry, 1973
- Binding of copper(II) to potentially tridentate amino acid ligandsJournal of the American Chemical Society, 1970
- The crystal structure of bis-L-histidinecopper(II) dinitrate dihydrateActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1969