Interleukin-3 supports growth of mouse pre-B-cell clones in vitro
- 1 May 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 309 (5964) , 126-131
- https://doi.org/10.1038/309126a0
Abstract
Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells in vitro.Keywords
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