Cigarettes, Sex, and Lung Adenocarcinoma

Abstract
For the past 50 years, the winds of change have been blowing through the epidemiology and demographics of lung cancer. Worldwide changes in the incidences, sex ratios, smoking associations, and pathologic types of lung cancer have been dramatic. Such rapid, extensive, and global changes are unprecedented and have not been observed for any other major form of human cancer. In this issue of the Journal, Thun et al. ( 1 ) explore the reasons for one of these changes, the explosive rise in the relative and absolute incidences of lung adenocarcinoma in both sexes.

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